Obesity is steadily becoming the greatest health problem in the developed world. The prevalence of overweight and obesity has reached pandemic proportions worldwide. It has recently been estimated that 1.1 billion people are overfed and overweight (1). It causes impaired function of the large arteries, which might be the consequence of metabolic dysregulation, inflammatory pathways, obstructive sleep apnea, or other mechanisms
The commonly used measurement to assess carotid “atherosclerosis” is intima media thickness (IMT). Recently, however, newer measurements such as assessment of plaque area or total plaque volume (TPV) have been suggested to represent a potentially more powerful approach, since these measurements in higher dimensions evaluate plaque burden in the carotid system and hold great sensitivity and discrimination [6-8]. IMT and TPV, however, are not interchangeable
Cigarette smoking is a causative factor for premature atherosclerosis [1,2]. However, the exact mechanism of smoking-induced damage to the arterial wall and its relation to the atherosclerotic process is still largely obscure. The adverse effects of smoking on vascular wall structure has been historically evaluated by autopsy studies
Atherosclerosis is a progressive disease characterised by the accumulation of lipids and fibrous elements in the large arteries [1]. The early lesions of atherosclerosis consist of subendothelial cholesterol-engorged macrophages called foam cells. More advanced lesions are characterised by the accumulation of lipid-rich necrotic debris and smooth muscle cells. Fibrous lesions typically have a fibrous cap [...]
Metabolic syndrome is a cluster of metabolic abnormalities defined as the clustering of several cardiovascular risk factors in an individual including visceral obesity, hypertension (HT), hypertriglyceridemia, low high-density lipoprotein cholesterolemia, and impaired glucose tolerance
Cerebrovascular disease (stroke) is the third lead- ing cause of death in the United States, accounting for approximately 400,000 new cases diagnosed each year and over 163,000 deaths in 2002